Dual-chamber syringe with dual-lumen intravenous set

ABSTRACT

A dual-chamber syringe may include an end wall and a primary plunger. The primary plunger may include a primary stopper. The primary stopper may form a primary chamber with the end wall. A secondary plunger may be in mechanical association with the primary plunger. The secondary plunger may include a secondary stopper. The secondary stopper may form a secondary chamber with the primary stopper. A primary nozzle may extend from the end wall and may be in fluid communication with the primary chamber. A secondary nozzle may extend from the end wall and may be in fluid communication with the secondary chamber.

CROSS REFERENCE

This application claims priority from Provisional U.S. Application Ser.No. 62/744,500 filed on Oct. 11, 2018, and entitled DUAL-CHAMBER SYRINGEWITH DUAL-LUMEN INTRAVENOUS SET.

BACKGROUND

The delivery of medical fluids to fluid-restricted patients oftenincludes administering the medical fluid intravenously through anintravenous (IV) set from a fluid source at low flow rates. Traditionalpractice often involves breaking the line to deliver an IV push, whichcan be time consuming at such low flow rates. Other conventionalpractices may involve administering a priming solution to thefluid-restricted patient via a pump before delivering the medical fluid,which may delay the medical fluid from being administered to thefluid-restricted patient in a timely fashion.

BRIEF DESCRIPTION OF THE DRAWINGS

The accompanying drawings, which are included to provide furtherunderstanding of the subject technology and are incorporated in andconstitute a part of this description, illustrate aspects of the subjecttechnology and, together with the specification, serve to explainprinciples of the subject technology.

FIG. 1 illustrates a side view of a dual-chamber syringe, with portionssectioned and broken away to show details, in accordance with aspects ofthe present disclosure.

FIG. 2 illustrates a perspective view of the dual-chamber syringedepicted in FIG. 1 in accordance with aspects of the present disclosure.

FIG. 3 illustrates a cross-sectional perspective view, taken along line3-3 of the dual-chamber syringe of FIG. 1, depicting an end wall of thesyringe in accordance with aspects of the present disclosure.

FIG. 4 illustrates a detailed cross-sectional view of a primary plungerof the dual-chamber syringe depicted in FIG. 1 in accordance withaspects of the present disclosure.

FIG. 5 illustrates a detailed cross-sectional perspective view of thedual-chamber syringe of FIG. 1 with an activator in an inactivated statein accordance with aspects of the present disclosure.

FIG. 6 illustrates a detailed plan view of a snap lock of the primaryplunger depicted in FIG. 5 in accordance with aspects of the presentdisclosure.

FIG. 7 illustrates a detailed perspective view of the activator depictedin FIG. 5, in an activated state, in accordance with aspects of thepresent disclosure.

FIG. 8 illustrates a plan view of a dual-lumen intravenous (IV) set inaccordance with aspects of the present disclosure.

FIG. 9 illustrates a plan view of the dual-lumen IV set of FIG. 8, withportions sectioned away and in phantom to depict interior details of thedual-lumen IV set in accordance with aspects of the present disclosure.

FIG. 10 illustrates a detailed perspective view of a dual-lumen tubeadapter of the dual-lumen IV set of FIG. 9 in accordance with aspects ofthe present disclosure.

FIG. 11 illustrates a perspective view of a dual-chamber syringe adapterin accordance with aspects of the present disclosure.

FIG. 12 illustrates a cross-sectional plan view taken along line 12-12of FIG. 11 in accordance with aspects of the present disclosure.

FIG. 13 illustrates a perspective view of a flush syringe adapter inaccordance with aspects of the present disclosure.

FIG. 14 illustrates a cross-sectional plan view taken along line 14-14of FIG. 13 in accordance with aspects of the present disclosure.

FIG. 15 illustrates a plan view of the dual-lumen IV set in use with aflush syringe in a pre-priming state, with portions sectioned and brokenaway to depict internal fluid passages, in accordance with aspects ofthe present disclosure.

FIG. 16 illustrates a plan view of the dual-lumen IV set in use with theflush syringe of FIG. 15 in a post-priming state, with portionssectioned and broken away to depict internal fluid passages, inaccordance with aspects of the present disclosure.

FIG. 17 illustrates a plan view of the dual-chamber syringe of FIG. 1,in a pre-filled state and in use with a vial, with portions sectionedand broken away to depict internal fluid passages, in accordance withaspects of the present disclosure.

FIG. 18 illustrates a plan view of the dual-chamber syringe of FIG. 17,in a post-filled state with the vial and the dual-chamber syringeadapter removed from the dual-chamber syringe, with portions sectionedand broken away to depict internal fluid passages, in accordance withaspects of the present disclosure.

FIG. 19 illustrates a plan view of a fluid delivery system in apre-priming of medication state, depicting the dual-chamber syringe ofFIG. 1 in use with the dual-lumen IV set of FIG. 8, with portionssectioned and broken away to depict internal fluid passages, inaccordance with aspects of the present disclosure.

FIG. 20 illustrates a plan view of the fluid delivery system of FIG. 19in a post-priming of medication state, depicting the dual-lumen IV setprimed with medication, with portions sectioned and broken away todepict internal fluid passages, in accordance with aspects of thepresent disclosure.

FIG. 21 illustrates a plan view of the fluid delivery system of FIG. 19in a pre-flushing state, with portions sectioned and broken away todepict internal fluid passages, in accordance with aspects of thepresent disclosure.

FIG. 22 illustrates a plan view of the fluid delivery system of FIG. 19in a post-flushing state, with portions sectioned and broken away todepict internal fluid passages, in accordance with aspects of thepresent disclosure.

FIGS. 23-26 illustrates detailed views of the dual-chamber syringetransitioning from the pre-flushing state depicted in FIG. 21 to thepost-flushing state depicted in FIG. 22.

DETAILED DESCRIPTION

In the following detailed description, specific details are set forth toprovide an understanding of the subject technology. It will be apparent,however, to one ordinarily skilled in the art that the subjecttechnology may be practiced without some of these specific details. Inother instances, well-known structures and techniques have not beenshown in detail so as not to obscure the subject technology.

A phrase such as “an aspect” does not imply that such aspect isessential to the subject technology or that such aspect applies to allconfigurations of the subject technology. A disclosure relating to anaspect may apply to all configurations, or one or more configurations.An aspect may provide one or more examples of the disclosure. A phrasesuch as “an aspect” may refer to one or more aspects and vice versa. Aphrase such as “an embodiment” does not imply that such embodiment isessential to the subject technology or that such embodiment applies toall configurations of the subject technology. A disclosure relating toan embodiment may apply to all embodiments, or one or more embodiments.An embodiment may provide one or more examples of the disclosure. Aphrase such “an embodiment” may refer to one or more embodiments andvice versa. A phrase such as “a configuration” does not imply that suchconfiguration is essential to the subject technology or that suchconfiguration applies to all configurations of the subject technology. Adisclosure relating to a configuration may apply to all configurations,or one or more configurations. A configuration may provide one or moreexamples of the disclosure. A phrase such as “a configuration” may referto one or more configurations and vice versa.

FIGS. 1-25 illustrate a fluid delivery system including asyringe-pump-compatible, dual-chamber syringe couplable to a dual-lumenintravenous (IV) set. The fluid delivery system is configured to removepriming solution from the dual-lumen IV set for reserve in thedual-chamber syringe, deliver medication at a pre-determined flow rate,and administer remaining medication residing in the dual-lumen IV set byrestoring the reserved priming solution in the dual-chamber syringe tothe dual-lumen IV set.

FIGS. 1-6 illustrate an embodiment of a dual-chamber syringe 110 of afluid delivery system 100 (shown in FIG. 19). In some embodiments, thedual-chamber syringe 110 includes a cylindrical syringe barrel 112, anend wall 114, and a syringe collar 116. The end wall 114 is disposed ata first end 118 of the syringe barrel 112 while the syringe collar 116is disposed at a second end 120 of the syringe barrel 112, which isopposite the first end 118. The syringe collar 116 extends radiallyoutwardly from the syringe barrel 112 proximate the second end 120. Thesyringe barrel 112 includes a cylindrical inner chamber 122 extendingbetween the end wall 114 and the syringe collar 116.

With particular reference to FIG. 3, a grooved channel 124 is recessedin an inner face 126 of the end wall 114. The inner face 126 faces theinner chamber 122 and is disposed therein. The channel 124 includes anotch end 128, a passage end 130, and a divot 132 disposed between thenotch end 128 and the passage end 130. In some aspects, the channel 124includes opposing beveled walls 134, which extend between the notch end128 and the divot 132 and between the divot 132 and the passage end 130.The notch end 128 is in fluid communication with a notch 136, which isdisposed in the syringe barrel 112 at an intersection of the syringebarrel 112 and the end wall 114 proximate the first end 118. The notch136 extends axially inwardly from the end wall 114 within the innerchamber 122. The passage end 130 is in fluid communication with apassage 138 disposed through the end wall 114. In some aspects, thechannel 124 extends along a portion of a diameter of the inner face 126.The notch 136, the channel 124, and the passage 138 collectively form aflushing fluid flow path of which the features and functionality will bedescribed in more detail below.

The dual-chamber syringe 110 also includes an internal tube 140. Theinternal tube 140 is disposed through the divot 132 and the inner face126 of the end wall 114 and extends axially inwardly within the innerchamber 122. The internal tube 140 terminates within the inner chamber122 and is offset axially inwardly with respect to the syringe collar116. In some aspects, the internal tube 140 extends substantiallycentrally through the divot 132 and the inner face 126 of the end wall114 and is disposed centrally within the inner chamber 122.

The dual-chamber syringe 110 also includes a primary nozzle 142 and asecondary nozzle 144. Both the primary nozzle 142 and the secondarynozzle 144 extend axially outwardly from the end wall 114 and aredisposed externally with respect to the inner chamber 122. In someaspects, the secondary nozzle 144 is disposed centrally on the end wall114. The secondary nozzle 144 is coaxially aligned with the internaltube 140 and is in fluid communication with the internal tube 140. Theprimary nozzle 142 is radially offset on the end wall 114 from thesecondary nozzle 144. The primary nozzle 142 is in fluid communicationwith a primary chamber 145 of the inner chamber 122 via the passage 138.A nozzle guide 143 also extends axially outwardly from the end wall 114and surrounds both the primary nozzle 142 and the secondary nozzle 144to facilitate connecting the dual-chamber syringe 110 to other medicalcomponents. In some aspects, the primary nozzle 142 and the secondarynozzle 144 are asymmetrical to prevent reversed or backwards coupling ofthe dual-chamber syringe 110 to the dual-lumen IV set (800). In someaspects, the primary nozzle 142 and the secondary nozzle 144 are maleLuer connectors. In other aspects, the primary nozzle 142 is a male Luerconnector and the secondary nozzle 144 is a needle-free connector. Inyet other aspects, the primary nozzle 142 is a needle-free connector andthe secondary nozzle 144 is a male Luer connector.

Moreover, the dual-chamber syringe 110 includes a primary plunger 146and a secondary plunger 148. The primary plunger 146 is in mechanicalassociation with the secondary plunger 148, such that both are receivedby the inner chamber 122 and are configured for slidable movement withinthe inner chamber 122. The primary plunger 146 includes a primarystopper 150, a primary head 152, and a rod 154 extending between theprimary stopper 150 and the primary head 152. The primary stopper 150 isdisposed at a first rod end 156 of the rod 154 and the primary head 152is disposed at a second rod end 158 of the rod 154. The primary plunger146 is arranged within the inner chamber 122, such that a primarychamber 159 is disposed between the primary stopper 150 and the innerface 126 of the end wall 114. The primary plunger 146 includes a primaryreceiving aperture 160 disposed centrally through the primary stopper150. The rod 154 extends from the primary stopper 150 and includes aprimary inner cavity 162, such that the primary inner cavity 162 isaligned with the primary receiving aperture 160. The primary receivingaperture 160 and the primary inner cavity 162 are configured to slidablyreceive the internal tube 140 of the dual-chamber syringe 110. In someaspects, a first primary O-ring 164 is disposed in the primary receivingaperture 160, such that the internal tube 140 is slidably and sealinglyreceived by the first primary O-ring 164 and is slidably received by theprimary inner cavity 162. A chamber passage 166 is disposed through therod 154 proximate an intersection of the rod 154 and the primary stopper150. In some aspects, a second primary O-ring 168 is disposed around theprimary stopper 150 for sealing engagement with syringe barrel 112.

The primary plunger 146 includes a lock member 170 disposed on the rod154 between the primary inner cavity 162 and the primary head 152. Withparticular reference to FIG. 6, the lock member 170 includes opposed rodflanges 172. Each rod flange of the opposed rod flanges 172 includes atapered tab 174, which protrudes radially outwardly and tapers axiallytowards the primary head 152. The opposed rod flanges 172 aredepressible radially inwardly toward each other. The lock member 170 ismechanically associated with components of the secondary plunger 148 toreleasably lock with the primary plunger 146, which will be described inmore detail below.

The secondary plunger 148 includes a secondary stopper 176, a secondaryhead 178, and a body 180 extending between the secondary stopper 176 andthe secondary head 178. The secondary stopper 176 is disposed at a firstbody end 182 of the body 180 and the secondary head 178 is disposed at asecond body end 184 of the body 180. The body 180 includes a mainsection 186 and a neck section 188. In some aspects, the main section186 of the body 180 includes wings including a plus-sign (e.g., +)cross-section. The main section 186 transitions to the neck section 188at a tapered section 190. In some aspects, the neck section 188 includesa neck 192 disposed between the tapered section 190 and the secondaryhead 178. The neck 192 includes, sequentially in a direction from thetapered section 190 to the secondary head 178, first opposed plungerslots 194, second opposed plunger slots 196, opposed activator lockslots 198, and opposed activator rest slots 200. Moreover, the secondaryplunger 148 includes a secondary receiving aperture 201 disposedcentrally through the secondary stopper 176 and a head aperture 202disposed centrally through the secondary head 178. The secondary plunger148 includes a secondary inner cavity 203 extending from the secondarystopper 176 at the secondary receiving aperture 201 to the secondaryhead 178 at the head aperture 202. The secondary receiving aperture 201and the secondary inner cavity 203 are configured to slidably receivethe rod 154 of the primary plunger 146. In such an arrangement withinthe inner chamber 122, a secondary chamber 199 of the inner chamber 122is disposed between the secondary stopper 176 and the primary stopper150. In some aspects, a first secondary O-ring 204 is disposed in thesecondary receiving aperture 201, such that the rod 154 is slidably andsealingly received by the first secondary O-ring 204 and is slidablyreceived by the secondary inner cavity 203. In some aspects, a secondsecondary O-ring 205 is disposed around the secondary stopper 176 forsealing engagement with the syringe barrel 112.

Opposed lock flanges 206 protrude outwardly from the neck 192 and extendaxially alongside the neck 192. A nub 208 protrudes radially inwardlyfrom each lock flange of the opposed lock flanges 206. The nubs 208 arealigned with the second opposed plunger slots 196. The opposed lockflanges 206 are configured to urge radially inwardly toward each other,such that nubs 208 are received by the second opposed plunger slots 196.The opposed lock flanges 206 are deformable and configured to be urgedradially outwardly away from each other when engaged with a pin 209 a.For example, the pin 209 a includes a pull tab 209 b formed to a clasp209c, such that the clasp 209c is removably fastened around the neck 192and arranged between the opposed lock flanges 206 and the neck 192 tourge the opposed lock flanges 206 radially outwardly. With the opposedlock flanges 206 urged radially outwardly away from each other, the nubs208 are held radially outwardly away from the second opposed plungerslots 196.

The secondary plunger 148 includes a seat 210 centrally recessed intothe secondary head 178 and aligned coaxially with the secondary innercavity 203 and the head aperture 202. The secondary plunger 148 alsoincludes an activator 212. The activator 212 includes an activator body214 and an activator head 216, which sits on the activator body 214. Theactivator body 214 is substantially cylindrical and includes opposedactivator flanges 218 formed in the activator body 214. Each activatorflange of the opposed activator flanges 218 includes a tapered tab 220,which protrudes radially outwardly and tapers axially inwardly. Theopposed activator flanges 218 are depressible radially inwardly towardeach other. The activator body 214 is received by the head aperture 202,such that, in the inactivated state of the activator 212, the taperedtabs 220 of the opposed activator flanges 218 are received by theopposed activator rest slots 200 and, in an activated state of theactivator 212, the tapered tabs 220 are received by, and seated at, theopposed activator lock slots 198 while the activator head 216 isreceived by the seat 210. Moreover, when the dual-chambered syringe 110is assembled, a resilient member 222 is disposed within the neck 192between the activator head 216 and the primary head 152 of the primaryplunger 146. The resilient member 222 is in an uncompressed state whenthe activator 212 is in the inactivated state and is in a compressedstate when the activator 212 is in the activated state.

With reference to FIGS. 8-10, the fluid delivery system 100 alsoincludes a dual-lumen intravenous (IV) set 800, which is couplable tothe dual-chamber syringe 110. Although the dual-lumen IV set 800 isillustrated with broken lines depicting a shortened length, it should beunderstood that the length of the dual-lumen IV set 800 can be anylength including, but not limited to, 1 meter, 2 meters, 3 meters, etc.The dual-lumen IV set 800 includes a connector 810, a valve housing 812,a valve 814, a primary lumen 816, a secondary lumen 818, and an adapter820. The connector 810 includes an exit port 822 and a channel 824fluidly connected to the exit port 822. The connector 810 is configuredto couple with a medical device, such as, for example, a catheter (nowshown). Although the fluid delivery system 100 is illustrated with onedual-lumen IV set 800, it is within the scope of the present applicationthat the fluid delivery system 100 includes multiple dual-lumen IV setsto deliver multiple drugs via multiple dual-chamber syringes in one IVset. The channel 824 is also fluidly connected to a housing passage 826disposed in the valve housing 812. In some aspects, the channel 824tapers from the housing passage 826 toward the exit port 822. A housingport 828 is also disposed in the valve housing 812 and is in fluidcommunication with the housing passage 826. An end of each of theprimary lumen 816 and the secondary lumen 818 are received by, and influid communication with, the housing port 828. The other end of theprimary lumen 816 is in fluid communication with a primary duct 830disposed in the adapter 820 while the other end of the secondary lumen818 is in fluid communication with a secondary duct 832 also disposed inthe adapter 820, which is offset from the primary duct 830.

The valve 814 is disposed in the valve housing 812 and is configured toseal the housing port 828 from the housing passage 826 until apredetermined cracking pressure is achieved against the valve 814 fromthe housing port 828 at which point fluid is allowed to flow from thehousing port 828 past the valve 814 and to the housing passage 826. Insome aspects, the valve 814 is a one-way valve, such as, but not limitedto, a check valve or an anti-siphon valve. The predetermined crackingpressure can be selected to crack at any predetermine pressure, such as,for example, 1 psi (pounds per square inch) or a half psi.

The adapter 820 also includes a primary septum 834 and a secondaryseptum 836. The primary septum 834 is disposed in the primary duct 830.The primary septum 834 is configured to seal a primary port 838 of theadapter 820, which is disposed at an end of the primary duct 830, toprevent fluid flow from the primary port 838 to the primary duct 830when unengaged with a medical device. When the adapter 820 is coupled tothe dual-chamber syringe 110, however, the primary nozzle 142 engagesthe primary septum 834 allowing fluid from the primary nozzle 142 toflow through the primary port 838 to the primary lumen 816 via theprimary duct 830. The secondary septum 836 is disposed in the secondaryduct 832 and is configured to seal a secondary port 840 of the adapter820, which is disposed at an end of the secondary duct 832, to preventfluid flow from the secondary duct 832 to the secondary port 840 whenunengaged with a medical device. When the adapter 820 is coupled to thedual-chamber syringe 110, however, the secondary nozzle 144 engages thesecondary septum 836 allowing fluid from the secondary duct 832 to flowthrough the secondary port 840 to the secondary nozzle 144. Moreover, asecondary valve 842 is disposed in the secondary duct 832 to allow fluidflow from the secondary lumen 818 to the secondary nozzle 144 via thesecondary duct 832, but prevents fluid flow in the opposite directionfrom the secondary nozzle 144 to secondary lumen 818. In some aspects,the secondary valve 842 is a one-way valve, such as, but not limited toa duckbill valve or a check valve. Because in some aspects the primarynozzle 142 and the secondary nozzle 144 are asymmetrical, the primarynozzle 142 is configured to be received only by the primary port 838 andcannot be received by the secondary port 840 while the secondary nozzle144 is configured to be received only by the secondary port 840 andcannot be received by the primary port 838 to prevent reversed orbackwards coupling of the dual-chamber syringe 110 to the dual-lumen IVset 800.

The adapter 820 also includes a ridge 844 disposed around the exteriorand axially offset inwardly from the primary port 838 and the secondaryport 840. The ridge 844 is configured to removably snap fit or interlockwith a seat 846 disposed on the interior of the nozzle guide 143 whenthe dual-chamber syringe 110 and the dual-lumen IV set 800 are coupledtogether. In some aspects, a first plurality of serrations 848 isdisposed on the exterior of the adapter 820 to facilitate gripping whenbeing hand-held.

With reference to FIGS. 11-12, the fluid delivery system 100 alsoincludes a dual-chamber syringe adapter 1100. The dual-chamber syringeadapter 1100 is couplable to the dual-chamber syringe 110 and a vialadapter 1110 (shown in FIG. 17), which is in turn coupled to a vial 1112(also shown in FIG. 17). The dual-chamber syringe adapter 1100 isconfigured to transfer fluid in the vial 1112 to the dual-chambersyringe 110. The dual-chamber syringe adapter 1100 includes a maleconnector 1114, a primary nozzle receiver 1116, a secondary nozzlereceiver 1118, and a conduit 1120. In some aspects, a second pluralityof serrations 1121 is disposed on the exterior of the dual-chambersyringe adapter 1100 to facilitate gripping when being hand-held. Theconduit 1120 is disposed through the dual-chamber syringe adapter 1100and fluidly couples the male connector 1114 to the primary nozzlereceiver 1116. A nozzle seat 1122 is disposed in the secondary nozzlereceiver 1118 for sealing engagement with the secondary nozzle 144 andpreventing any fluid flow through the secondary nozzle 144. Thedual-chamber syringe adapter 1100 also includes a cap 1124 hingedlycoupled to the male connector 1114 for removably capping or closing themale connector 1114. In some aspects, the male connector 1114 is a maleLuer connector. The male connector 1114 is configured to couple with afemale connector of the vial adapter 1110. The primary nozzle receiver1116 is configured to matingly receive the primary nozzle 142 of thedual-chamber syringe 110 and the secondary nozzle receiver 1118 isconfigured to matingly receive the secondary nozzle 144 of thedual-chamber syringe 110 while an adapter ridge 1126 disposed on theexterior of the dual-chamber syringe adapter 1100 removably snap fits orinterlocks with the seat 846. When the dual-chamber syringe adapter 1100is coupled to the dual-chamber syringe 110 fluid in the vial 1112 iscapable of being drawn into the primary chamber 159 through the primarynozzle 142 via the vial adapter 1110, the male connector 1114, and theconduit 1120.

With reference to FIGS. 13 and 14, the fluid delivery system 100 alsoincludes a flush syringe adapter 1300. The flush syringe adapter 1300 iscouplable to a flush syringe 1310 (shown in FIG. 15) and the adapter 820of the dual-lumen IV set 800. The flush syringe adapter 1300 isconfigured to transfer fluid from the flush syringe 1310 to prime thedual-lumen IV set 800 with saline. The flush syringe adapter 1300includes a primary adapter nozzle 1312, a secondary adapter nozzle 1314,a syringe guide 1316, a female connector 1318, a primary passage 1320,and a secondary passage 1322. In some aspects, a third plurality ofserrations 1324 is disposed on the exterior of the flush syringe adapter1300 to facilitate gripping when being hand-held. The syringe guide 1316surrounds the primary adapter nozzle 1312 and the secondary adapternozzle 1314 to facilitate coupling the flush syringe adapter 1300 to thedual-lumen IV set 800 so that the primary adapter nozzle 1312 isreceived by the primary port 838 of the adapter 820 and the secondaryadapter nozzle 1314 is received by the secondary port 840. In someaspects, the primary adapter nozzle 1312 and the secondary adapternozzle 1314 are asymmetrical, such that the primary adapter nozzle 1312is configured to be received only by the primary port 838 and cannot bereceived by the secondary port 840 while the secondary adapter nozzle1314 is configured to be received only by the secondary port 840 andcannot be received by the primary port 838 to prevent reversed orbackwards coupling of the flush syringe adapter 1300 to the dual-lumenIV set 800. In some aspects, the primary adapter nozzle 1312 and thesecondary adapter nozzle 1314 are male Luer connectors. In otheraspects, the primary adapter nozzle 1312 is a male Luer connector andthe secondary adapter nozzle 1314 is a needle-free connector. In yetother aspects, the primary adapter nozzle 1312 is a needle-freeconnector and the secondary adapter nozzle 1314 is a male Luerconnector.

The primary passage 1320 is disposed between, and fluidly couples, theprimary adapter nozzle 1312 and an adapter port 1328 disposed at thefemale connector 1318. In some aspects, the female connector 1318 is afemale Luer connector. The female connector 1318 is configured to couplewith a male connector of the flush syringe 1310. In some aspects, themale connector of the flush syringe 1310 is a male Luer connector. Thesecondary passage 1322 is disposed between, and fluidly couples, thesecondary adapter nozzle 1314 and a vent 1330. A hydrophobic element1332 is disposed in the secondary passage 1322 and is configured toallow air from the secondary adapter nozzle 1314 to escape through thevent 1330, but when the hydrophobic element 1332 contacts liquid fluid(e.g., saline from the flush syringe 1310) it prevents the liquid fluidfrom flowing out of the vent 1330.

FIG. 15 illustrates the dual-lumen IV set 800 in use with the flushsyringe 1310 in a pre-priming state and FIG. 16 illustrates thedual-lumen IV set 800 in use with the flush syringe 1310 in apost-priming state. In order to prime the dual-lumen IV set 800, whichmay occur at a patient bedside, the flush syringe adapter 1300 iscoupled to the dual-lumen IV set 800, such that the primary adapternozzle 1312 and the secondary adapter nozzle 1314 are received by theprimary port 838 and the secondary port 840, respectively, and theadapter seat 1326 removably snap fits with the ridge 844 of the adapter820. With the flush syringe adapter 1300 coupled to the dual-lumen IVset 800, the dual-chamber syringe adapter 1100, which is pre-filled withsaline, is coupled to the flush syringe adapter 1300 via the femaleconnector 1318. The flush syringe 1310 delivers the saline through theadapter port 1328 and the primary passage 1320 into the primary port 838and the primary duct 830. The saline flows from the primary duct 830through the primary lumen 816 until it reaches the housing port 828 andthe valve 814. The pressure against the valve 814 is less than thepredetermined cracking pressure so the saline travels through thesecondary lumen 818 and the secondary valve 842. During this flowprocess, air in the dual-lumen IV set 800 has been pushed through thehydrophobic element 1332 and out the vent 1330, but once the salinecontacts the hydrophobic element 1332, it prevents the saline fromflowing any further. As the saline is prevented from flowing past thehydrophobic element 1332, the rest of the dual-lumen IV set 800 isprimed with the saline. After the dual-lumen IV set 800 is fully primed,it can then be coupled to a medical device, such as a catheter. With thedual-lumen IV set 800 coupled to the catheter, the rest of the saline inthe flush syringe 1310 is flushed through creating a pressure againstthe valve 814, because the hydrophobic element 1332 is preventing salineflow, that is higher than the predetermined cracking pressure, such thatthe valve 814 allows the saline to flow past to the housing passage 826and out the exit port 822 to the catheter. The flush syringe adapter1300, along with the flush syringe 1310, is then uncoupled from thedual-lumen IV set 800.

FIG. 17 illustrates the dual-chamber syringe 110 in a pre-filled stateand in use with the vial 1112 and FIG. 18 illustrates the dual-chambersyringe 110, in a post-filled state with the vial 1112 and thedual-chamber syringe adapter 1100 uncoupled from the dual-chambersyringe 110. The pin 209 a is inserted around the neck 192 urging theopposed lock flanges 206 radially outwardly, such that the nubs 208 areheld radially outwardly away from the second opposed plunger slots 196.With the nubs 208 arranged in this manner, the tapered tabs 174 of thelock member 170 are removably received at the second opposed plungerslots 196 locking the primary plunger 146 to the secondary plunger 148.With the activator 212 in the inactivated state, the tapered tabs 220 ofthe opposed activator flanges 218 are received by and seated at theopposed activator rest slots 200, such that the resilient member 222 isin its uncompressed state between the primary head 152 of the primaryplunger 146 and the activator head 216. This arrangement locks theprimary plunger 146 to the secondary plunger 148 so that the primarystopper 150 is offset from the secondary stopper 176 at a predetermineddistance, which can be preselected according to specific desires of apre-filled volume of the secondary chamber 199. The dual-chamber syringe110 is pre-filled with saline in the secondary chamber 199, asillustrated in FIG. 17.

In use, such as at a pharmacy environment, the activator 212 of thedual-chamber syringe 110 is activated by compressing the activator head216 axially inward, such that the tapered tabs 220 of the opposedactivator flanges 218 are depressed radially towards each other,unseated from the opposed activator rest slots 200, and received by theopposed activator lock slots 198 in locking fashion while the activatorhead 216 is received by the seat 210. In this arrangement, the resilientmember 222 is in its compressed state between the primary head 152 ofthe primary plunger 146 and the activator head 216 positioned at theseat 210. Allowing the resilient member 222 to be in the uncompressedstate before use can extend the shelf life of the dual-chamber syringe110. After activating the activator 212, the dual-chamber syringe 110 iscoupled to the dual-chamber syringe adapter 1100, such that the nozzleguide 143 facilitates the primary nozzle 142 being matingly insertedinto the primary nozzle receiver 1116 and the secondary nozzle 144 beingmatingly inserted into the secondary nozzle receiver 1118 while theadapter ridge 1126 removably snap fits or interlocks with the seat 846.With the secondary nozzle 144 received by the secondary nozzle receiver1118 and seated against the nozzle seat 1122, the saline is preventedfrom accidentally flowing out of the secondary chamber 199 during fluidtransfer from the vial 1112 to the dual-chamber syringe 110.

With the dual-chamber syringe adapter 1100 coupled to the dual-chambersyringe 110, the male connector 1114 is coupled to the vial adapter1110, which is coupled to the vial 1112. As the primary plunger 146 islocked to the secondary plunger 148, pulling the secondary head 178axially away from the syringe collar 116 will draw the fluid in the vial1112 (e.g., medicine) through the dual-chamber syringe adapter 1100 andthe primary nozzle 142 and into the primary chamber 159 via the passage138, and without disturbing the saline in the secondary chamber 199, theinternal tube 140, and the primary inner cavity 162. Once the desiredamount of medicine is drawn into the primary chamber 159 thedual-chamber syringe adapter 1100 can be uncoupled from the dual-chambersyringe 110, as depicted in FIG. 18.

FIG. 19 illustrates the dual-chamber syringe 110 of the fluid deliverysystem 100 in a pre-priming of medication state and in use with thedual-lumen IV set 800. The dual-lumen IV set 800 is primed with salineand is fluidly coupled to a catheter 1910. The dual-lumen IV set 800 isalso fluidly coupled to the dual-chamber syringe 110, which is inmechanical engagement with a syringe pump 1920. While the syringe pump1920 securely supports the syringe barrel 112, the syringe pump 1920 isalso in mechanical engagement with the secondary head 178 to selectivelycontrol axially movement of the secondary plunger 148.

From the pre-priming of medication state, the dual-chamber syringe 110and dual-lumen IV set 800 transition to a post-priming of medicationstate, as illustrated in FIG. 20. The transition involves removing thepin 209 a from the neck 192, such that the opposed lock flanges 206 areurged radially towards each other and the nubs 208 engage the taperedtabs 174 of the lock member 170 releasing the tapered tabs 174 from thesecond opposed plunger slots 196. With the secondary head 178 held inplace by the syringe pump 1920, the release or unseating of the taperedtabs 174 from the second opposed plunger slots 196 allows the resilientmember 222, in the compressed state, to urge against the primary head152, which in turn urges the primary plunger 146 axially toward the endwall 114. As the primary plunger 146 is urged axially toward the endwall 114, the medication in the primary chamber 159 is forced throughthe passage 138 and out the primary nozzle 142 into the primary duct 830to the primary lumen 816. At the same time, and because the pressureagainst the valve 814 is less than the predetermined cracking pressure,the medication is displacing the saline that was primed in thedual-lumen IV set 800 to travel out the secondary port 840 and throughthe secondary nozzle 144 to fill the secondary chamber 199 via theinternal tube 140, the primary inner cavity 162, and the chamber passage166. The primary plunger 146 continues to prime the dual-lumen IV set800 with the medication until the tapered tabs 174 are received by, andseated against, the first opposed plunger slots 194, which prevents theresilient member 222 from urging the primary plunger 146 any further.

From the post-priming of medication state, the dual-chamber syringe 110and dual-lumen IV set 800 transition to a pre-flushing state, asillustrated in FIG. 21. The transition involves the syringe pump 1920moving the secondary head 178 of the secondary plunger 148 axiallytoward the end wall 114 to deliver the remaining medication in theprimary chamber 159 through the passage 138 and the primary nozzle 142to the primary duct 830 and the primary lumen 816. Because the secondaryvalve 842 prevents saline flow from the secondary chamber 199 to thesecondary lumen 818, pressure is increased against the valve 814 as thesecondary plunger 148 is moved axially and is greater than thepredetermined cracking pressure, such that the axially movement of thesecondary plunger 148 forces the medication past the valve 814 and intothe housing passage 826 to the catheter 1910 via the channel 824 and theexit port 822. As the secondary plunger 148 is being moved axiallytoward the end wall 114, the tapered tabs 174 are unseated from thefirst opposed plunger slots 194 and are moved towards the second opposedplunger slots 196.

Once the primary stopper 150 abuts the inner face 126 of the end wall114, the dual-chamber syringe 110 and dual-lumen IV set 800 transitionsfrom the pre-flushing state to a post-flushing state, as illustrated inFIG. 22. The transition is illustrated in FIGS. 23-26. FIG. 23illustrates the pre-flushing state with the primary stopper 150 abuttingthe inner face 126 of the end wall 114 and medication residing in thechannel 124 and the notch 136. The second primary O-ring 168 seals thenotch 136 and prevents the medication from flowing into the secondarychamber 199. As the secondary plunger 148 is continued to be movedaxially toward the end wall 114 during the transition, the pressureagainst the second primary O-ring 168 increases, such that the saline inthe secondary chamber 199 is forced past the second primary O-ring 168and through the notch 136 into the channel 124 and forces the medicationto the primary nozzle 142 via the passage 138. The syringe pump 1920continues to axially move the secondary plunger 148, such that thesaline is forced from the secondary chamber 199 to flush the medicationfrom the channel 124. In this manner, the saline forces the medicationthrough the primary lumen 816 so that all of the medication is deliveredto the patient and the dual-lumen IV set 800 is primed with saline.

In some aspects, the dual-chamber syringe is pre-loaded with saline inthe secondary chamber 199. In some aspects, the secondary chamber 199 isconfigured to receive the priming solution from the dual-lumen IV set800, but is not utilized for reserved flushing. In some aspects, thesecondary chamber 199 is configured to stop the secondary plunger 148when receiving priming solution from the dual-lumen IV set 800 and isconfigured to indicate the dual-chamber syringe 110 is ready to infusemedication. In some aspects, the fluid delivery system 100 includes avalve lock to prevent fluid from being delivered to a patient duringpriming. In some aspects, the priming volume is selectable in 0.1 mLincrements. In some aspects, the secondary plunger 148 includes aplunger handle base that rotates to allow the plunger rod to rotate anddisengage while maintaining friction with a syringe pump paddle. In someaspects, the secondary plunger 148 is released automatically, instead ofwith a pin 209 a, at a certain plunger depth so that infusion is notinterrupted and does not require human interaction. In some aspects, thefluid delivery system 100 includes vents to vent residual air bubblesvia air-permeable filters. In some aspects, the fluid delivery system100 is configured to pre-set and limit the priming volume via a pinwhich limits plunger travel.

The foregoing description is provided to enable a person skilled in theart to practice the various configurations described herein. While thesubject technology has been particularly described with reference to thevarious figures and configurations, it should be understood that theseare for illustration purposes only and should not be taken as limitingthe scope of the subject technology.

There may be many other ways to implement the subject technology.Various functions and elements described herein may be partitioneddifferently from those shown without departing from the scope of thesubject technology. Various modifications to these configurations willbe readily apparent to those skilled in the art, and generic principlesdefined herein may be applied to other configurations. Thus, manychanges and modifications may be made to the subject technology, by onehaving ordinary skill in the art, without departing from the scope ofthe subject technology.

As used herein, the phrase “at least one of” preceding a series ofitems, with the term “and” or “or” to separate any of the items,modifies the list as a whole, rather than each member of the list (i.e.,each item). The phrase “at least one of” does not require selection ofat least one of each item listed; rather, the phrase allows a meaningthat includes at least one of any one of the items, and/or at least oneof any combination of the items, and/or at least one of each of theitems. By way of example, the phrases “at least one of A, B, and C” or“at least one of A, B, or C” each refer to only A, only B, or only C;any combination of A, B, and C; and/or at least one of each of A, B, andC.

Furthermore, to the extent that the term “include,” “have,” or the likeis used in the description or the claims, such term is intended to beinclusive in a manner similar to the term “comprise” as “comprise” isinterpreted when employed as a transitional word in a claim. The word“exemplary” is used herein to mean “serving as an example, instance, orillustration.” Any embodiment described herein as “exemplary” is notnecessarily to be construed as preferred or advantageous over otherembodiments.

A reference to an element in the singular is not intended to mean “oneand only one” unless specifically stated, but rather “one or more.” Theterm “some” refers to one or more. All structural and functionalequivalents to the elements of the various configurations describedthroughout this disclosure that are known or later come to be known tothose of ordinary skill in the art are expressly incorporated herein byreference and intended to be encompassed by the subject technology.Moreover, nothing disclosed herein is intended to be dedicated to thepublic regardless of whether such disclosure is explicitly recited inthe above description.

While certain aspects and embodiments of the subject technology havebeen described, these have been presented by way of example only, andare not intended to limit the scope of the subject technology. Indeed,the novel methods and systems described herein may be embodied in avariety of other forms without departing from the spirit thereof. Theaccompanying claims and their equivalents are intended to cover suchforms or modifications as would fall within the scope and spirit of thesubject technology.

What is claimed is:
 1. A dual-chamber syringe, comprising: an end wall;a primary plunger comprising a primary stopper, the primary stopperforming a primary chamber with the end wall; a secondary plunger inmechanical association with the primary plunger, the secondary plungercomprising a secondary stopper, the secondary stopper forming asecondary chamber with the primary stopper; a primary nozzle extendingfrom the end wall, the primary nozzle in fluid communication with theprimary chamber; and a secondary nozzle extending from the end wall, thesecondary nozzle in fluid communication with the secondary chamber. 2.The dual-chamber syringe of claim 1, wherein the secondary nozzleextends centrally from the end wall.
 3. The dual-chamber syringe ofclaim 2, wherein the primary nozzle is radially offset from thesecondary nozzle.
 4. The dual-chamber syringe of claim 1, wherein theprimary nozzle and the secondary nozzle are asymmetric.
 5. Thedual-chamber syringe of claim 1, further comprising a nozzle guideextending from the end wall and surrounding the primary nozzle and thesecondary nozzle.
 6. The dual-chamber syringe of claim 1, wherein theprimary plunger is lockable to the secondary plunger.
 7. Thedual-chamber syringe of claim 1, wherein the end wall comprises achannel.
 8. The dual-chamber syringe of claim 7, wherein the secondarychamber is in fluid communication with the primary nozzle via thechannel when the dual-chamber syringe is transitioning from apre-flushing state to a post-flushing state.
 9. The dual-chamber syringeof claim 1, wherein the secondary nozzle is in fluid communication withthe secondary chamber via an internal tube extending from the end wall.10. The dual-chamber syringe of claim 9, wherein the internal tube isreceived by a primary inner cavity of the primary plunger.
 11. Amulti-lumen intravenous (IV) set, comprising: an adapter comprising aprimary duct and a secondary duct; a valve housing comprising a housingport and a housing passage; a primary lumen in fluid communication withthe primary duct and the housing port; a secondary lumen in fluidcommunication with the secondary duct and the housing port; and a valvedisposed in the valve housing, the valve comprising a cracking pressure,wherein the valve is configured to prevent fluid flow from the housingport to the housing passage when pressure against the valve is less thanthe cracking pressure, and wherein the valve is configured to allowfluid flow from the housing port to the housing passage when pressureagainst the valve is greater than the cracking pressure.
 12. Themulti-lumen IV set of claim 11, wherein the primary lumen is in fluidcommunication with the secondary lumen when pressure against the valveis less than the cracking pressure.
 13. The multi-lumen IV set of claim11, further comprising a primary septum disposed in the primary duct anda secondary septum disposed in the secondary duct.
 14. The multi-lumenIV set of claim 13, wherein the primary septum is configured to seal aprimary port disposed at the primary duct to prevent fluid flow from theprimary port to the primary duct when unengaged with a medical deviceand is configured to allow fluid flow from the primary port to theprimary duct when engaged with the medical device, and wherein thesecondary septum is configured to seal a secondary port disposed at thesecondary duct to prevent fluid flow from the secondary port to thesecondary duct when unengaged with the medical device and is configuredto allow fluid flow from the secondary port to the secondary duct whenengaged with the medical device.
 15. The multi-lumen IV set of claim 14,further comprising a secondary valve disposed in the secondary duct, thesecondary valve configured to allow fluid flow from the secondary lumento the secondary port and to prevent fluid flow from the secondary portto the secondary lumen.
 16. The multi-lumen IV set of claim 15, whereinthe secondary valve is a check valve.
 17. The multi-lumen IV set ofclaim 14, wherein the primary port and the secondary port areasymmetrical.
 18. A fluid delivery system, comprising: a dual-chambersyringe comprising, an end wall; a primary plunger comprising a primarystopper, the primary stopper forming a primary chamber with the endwall; a secondary plunger in mechanical association with the primaryplunger, the secondary plunger comprising a secondary stopper, thesecondary stopper forming a secondary chamber with the primary stopper;a primary nozzle extending from the end wall, the primary nozzle influid communication with the primary chamber; a secondary nozzleextending from the end wall, the secondary nozzle in fluid communicationwith the secondary chamber; and a multi-lumen intravenous setcomprising, an adapter comprising a primary port and a secondary port,the primary port fluidly coupled to the primary nozzle and the secondaryport fluidly coupled to the secondary nozzle; a valve housing comprisinga housing port and a housing passage; a primary lumen in fluidcommunication with a primary duct disposed in the adapter and in fluidcommunication with the housing port; a secondary lumen in fluidcommunication with a secondary duct disposed in the adapter and in fluidcommunication with the housing port; and a valve disposed in the valvehousing, the valve comprising a cracking pressure, wherein the valve isconfigured to prevent fluid flow from the housing port to the housingpassage when pressure against the valve is less than the crackingpressure, and wherein the valve is configured to allow fluid flow fromthe housing port to the housing passage when pressure against the valveis greater than the cracking pressure.
 19. The fluid delivery system ofclaim 18, wherein the primary plunger comprises a lock member configuredto removably lock the primary plunger to the secondary plunger.
 20. Thefluid delivery system of claim 18, a secondary valve disposed in thesecondary duct, the secondary valve configured to allow fluid flow fromthe secondary lumen to the secondary port and to prevent fluid flow fromthe secondary port to the secondary lumen.